Description

2-Bromo-4,5-Difluorobenzothiazole is a high-value halogenated heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its role as a versatile intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require precise and reliable fluorinated synthons.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides, leveraging the biological activity of the benzothiazole and fluorine motifs.
• Material Science Research: Serves as a building block for organic light-emitting diodes (OLEDs), liquid crystals, and other electronic materials due to its electron-deficient aromatic system.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and asymmetric synthesis.
• Fluorinated Dye and Pigment Synthesis: Acts as a core component for creating dyes and pigments with enhanced stability and unique optical properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.

Basic Information

Product Name	2-Bromo-4,5-Difluorobenzothiazole
CAS No.	898748-72-6
Molecular Formula	C7H2BrF2NS
Molecular Weight	250.06 g/mol
Synonyms	2-Bromo-4,5-difluoro-1,3-benzothiazole; 4,5-Difluoro-2-bromobenzothiazole; Benzothiazole, 2-bromo-4,5-difluoro-; 898748-72-6; 2-Bromo-4,5-difluorobenzo[d]thiazole
EINECS	Contact for details

Quality Control

Our 2-Bromo-4,5-Difluorobenzothiazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment. We adhere to cGMP standards for pharmaceutical-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.