Description

Methyl 5-Bromo-2-Oxoindoline-7-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the oxindole class of heterocyclic compounds. This compound is of significant value for its role as a key building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel drug candidates, especially those targeting kinase inhibition and other therapeutic pathways.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of potent kinase inhibitors and other targeted small-molecule therapeutics.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the discovery of new chemical entities (NCEs).
• Organic Synthesis Building Block: Used in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex indoline-based motifs.
• Agrochemical Research: Potential intermediate for developing new active ingredients with specific biological activity.
• Academic & Contract Research: Employed in university and CRO settings for methodological development and the synthesis of specialized libraries for biological screening.

Basic Information

Product Name	Methyl 5-Bromo-2-Oxoindoline-7-Carboxylate
CAS No.	898747-32-5
Molecular Formula	C10H8BrNO3
Molecular Weight	270.08 g/mol
Synonyms	5-Bromo-2-oxo-2,3-dihydro-1H-indole-7-carboxylic acid methyl ester; Methyl 5-bromo-2-oxo-2,3-dihydro-1H-indole-7-carboxylate; 7-Methoxycarbonyl-5-bromooxindole; 5-Bromo-7-(methoxycarbonyl)indolin-2-one; 898747-32-5; 5-Bromo-2-oxindole-7-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 5-Bromo-2-Oxoindoline-7-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up processes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.