Description

n-Boc-5-Bromotryptophol is a protected indole derivative that serves as a crucial synthetic intermediate in advanced organic chemistry. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and biotechnology industries for the synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of tryptamine-based drug candidates, including potential serotonin receptor modulators and kinase inhibitors.
• Peptidomimetic Synthesis: Used in the construction of complex peptides and peptidomimetics where the indole scaffold is required, leveraging the protected amine and alcohol functionalities.
• Agrochemical Research: Serves as a precursor in developing novel crop protection agents and plant growth regulators that incorporate halogenated indole structures.
• Chemical Biology Probes: Employed in the design and synthesis of fluorescent tags, affinity probes, and other tools for studying biological systems and target engagement.
• Academic & Contract Research: Essential for methodology development, total synthesis projects, and discovery chemistry within academic institutions and CROs (Contract Research Organizations).
• Scale-up & Process Chemistry: Suitable for optimization and kilogram-scale production runs for clinical trial material and commercial manufacturing, thanks to its defined purity and stability.

Basic Information

Product Name	n-Boc-5-Bromotryptophol
CAS No.	898746-62-8
Molecular Formula	C₁₆H₂₀BrNO₃
Molecular Weight	354.24 g/mol
Synonyms	5-Bromo-N-Boc-tryptophol; tert-Butyl (5-bromo-1H-indol-3-yl)(2-hydroxyethyl)carbamate; 2-[(tert-Butoxycarbonyl)(5-bromo-1H-indol-3-yl)amino]ethanol; 1-(5-Bromo-1H-indol-3-yl)-2-[(tert-butoxycarbonyl)amino]ethanol; Boc-5-Br-Trp-ol; N-Boc-5-bromotryptamine alcohol derivative
EINECS	Contact for details

Quality Control

Our n-Boc-5-Bromotryptophol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.