Description

5,6-Difluoro-2-Indole Carboxylic Acid Methyl Ester is a high-value fluorinated indole derivative, a crucial synthetic intermediate in modern organic chemistry. Its core value lies in providing a versatile, functionalized scaffold for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical industry for the synthesis of novel active pharmaceutical ingredients (APIs) and by researchers in agrochemical discovery programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the difluoroindole moiety can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or precursor for advanced organic electronic materials, such as OLEDs and semiconductors, due to its conjugated indole system.
• Fluorescent Probe Synthesis: Utilized in creating specialized fluorophores and molecular probes for biochemical sensing and diagnostic applications.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in fluorination chemistry and heterocyclic compound synthesis.

Basic Information

Product Name	5,6-Difluoro-2-Indole Carboxylic Acid Methyl Ester
CAS No.	898746-30-0
Molecular Formula	C10H7F2NO2
Molecular Weight	211.17 g/mol
Synonyms	Methyl 5,6-Difluoro-1H-indole-2-carboxylate; 5,6-Difluoroindole-2-carboxylic Acid Methyl Ester; 2-Carbomethoxy-5,6-difluoroindole; 5,6-Difluoro-2-indolecarboxylic Acid Methyl Ester; 898746-30-0; 5,6-Difluoro-1H-indole-2-carboxylic acid methyl ester; Methyl 5,6-difluoro-1H-indole-2-carboxylate
EINECS	Contact for details

Quality Control

Our 5,6-Difluoro-2-Indole Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to consistent quality and traceability supports your regulatory and process development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.