Description

2,3(1H)-Isoquinolinedicarboxylic Acid, 3,4-Dihydro-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, 2-(1,1-Dimethylethyl) 3-Ethyl Ester is a sophisticated boronic ester derivative of isoquinoline, serving as a key synthetic intermediate in advanced organic synthesis. Its primary value lies in its role as a versatile building block for constructing complex molecular architectures via Suzuki-Miyaura cross-coupling reactions. This high-purity compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing new active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly for complex heterocyclic compounds targeting CNS disorders, oncology, and inflammation.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the isoquinoline scaffold and boronate functionality enable the creation of molecules with specific biological activity.
• Material Science: Serves as a monomer or functionalization agent in the synthesis of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and sensors for studying biological processes and enzyme activity.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form new carbon-carbon bonds, a cornerstone reaction in modern synthetic chemistry.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) engaged in methodological development and discovery chemistry.

Basic Information

Product Name	2,3(1H)-Isoquinolinedicarboxylic Acid, 3,4-Dihydro-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, 2-(1,1-Dimethylethyl) 3-Ethyl Ester
CAS No.	897374-85-5
Molecular Formula	C22H30BNO6
Molecular Weight	415.29 g/mol
Synonyms	3,4-Dihydro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3(1H)-isoquinolinedicarboxylic acid 2-tert-butyl 3-ethyl ester; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-tert-butyl 3-ethyl ester; 2-(tert-Butyl) 3-ethyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylate; 6-BPin-1,2,3,4-tetrahydroisoquinoline-2,3-dicarboxylic acid di-tert-butyl ester (related analog); Boronic ester isoquinoline derivative; CAS 897374-85-5; Suzuki coupling reagent.
EINECS	Contact for details

Quality Control

Our production of 2,3(1H)-Isoquinolinedicarboxylic Acid, 3,4-Dihydro-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, 2-(1,1-Dimethylethyl) 3-Ethyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. All materials undergo comprehensive analytical characterization, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.