Description

2H-Indol-2-One, 6-Chloro-3-[(3-Chloro-2-Fluorophenyl)Methylene]-1,3-Dihydro- is a high-purity, synthetically derived organic compound that serves as a critical advanced intermediate in modern pharmaceutical research and development. Its complex molecular architecture, featuring a chlorinated indolone core and a fluorinated benzylidene substituent, makes it a valuable scaffold for constructing novel active pharmaceutical ingredients (APIs). This compound is primarily sought by research institutions and pharmaceutical companies engaged in the discovery and synthesis of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• API Development: Serves as a precursor in the development of potential Active Pharmaceutical Ingredients (APIs), especially for targeted therapies.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for investigating enzyme function and cellular signaling mechanisms.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for exploratory synthetic chemistry and novel heterocyclic compound development.

Basic Information

Product Name	2H-Indol-2-One, 6-Chloro-3-[(3-Chloro-2-Fluorophenyl)Methylene]-1,3-Dihydro-
CAS No.	897365-76-3
Molecular Formula	C15H8Cl2FNO
Molecular Weight	308.13 g/mol
Synonyms	6-Chloro-3-[(3-chloro-2-fluorophenyl)methylene]-1,3-dihydro-2H-indol-2-one; 3-[(3-Chloro-2-fluorophenyl)methylene]-6-chloro-1,3-dihydro-2H-indol-2-one; (3Z)-6-Chloro-3-[(3-chloro-2-fluorophenyl)methylidene]-1,3-dihydro-2H-indol-2-one; 6-Chloro-3-(3-chloro-2-fluorobenzylidene)indolin-2-one; 897365-76-3; AGN-PC-0E7QJX; ZINC000644022909; AKOS025247067; 1,3-Dihydro-6-chloro-3-[(3-chloro-2-fluorophenyl)methylene]-2H-indol-2-one
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical characterization using techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical quality attributes. Our facilities and processes are designed to meet the stringent requirements of cGMP (Current Good Manufacturing Practice) standards for pharmaceutical intermediates, ensuring reliability for your research and development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.