Description

(S)-1'-((R)-3,3-Dimethyl-4-Oxo-1-Phenylazetidin-2-Yl)-3,3,5'-Trimethyl-1-Phenylspiro[Azetidine-2.3'-Indoline]-2',4-Dione is a sophisticated chiral spirocyclic compound that serves as a critical advanced pharmaceutical intermediate (API). Its complex, multi-ring structure makes it a valuable building block for the synthesis of novel, high-value active ingredients. This compound is primarily targeted at pharmaceutical research and development organizations engaged in creating new therapeutic agents, particularly in areas requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) or anti-cancer targets.
• Asymmetric Synthesis: Utilized in chiral synthesis due to its defined (S) and (R) stereocenters, enabling the production of enantiomerically pure compounds.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Used in scaling up synthetic routes for potential drug candidates during preclinical and early clinical development phases.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development of complex organic molecules.

Basic Information

Product Name	(S)-1'-((R)-3,3-Dimethyl-4-Oxo-1-Phenylazetidin-2-Yl)-3,3,5'-Trimethyl-1-Phenylspiro[Azetidine-2.3'-Indoline]-2',4-Dione
CAS No.	896746-05-7
Molecular Formula	C32H31N3O3
Molecular Weight	505.61 g/mol
Synonyms	Spiro[azetidine-2,3'-indoline]-2',4-dione, 1'-[(2R)-3,3-dimethyl-4-oxo-1-phenyl-2-azetidinyl]-3,3,5'-trimethyl-1-phenyl-, (2'S)-; (2'S)-1'-[(2R)-3,3-Dimethyl-4-oxo-1-phenyl-2-azetidinyl]-3,3,5'-trimethyl-1-phenylspiro[azetidine-2,3'-indoline]-2',4-dione; 896746-05-7; UNII-9P2V9Q4F1P; 9P2V9Q4F1P; CHEMBL3186665; AKOS025147324; SCHEMBL15520497.
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.