Description

(1S,2R)-2'-Oxospiro[Cyclopropane-1,3'-Indoline]-2-Carbonitrile is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and cyclopropane-fused indoline scaffold. This compound is of significant value for its role as a key chiral building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for constructing compound libraries in drug discovery programs targeting various diseases.
• Kinase Inhibitor Synthesis: Serves as a privileged structural motif in the design and synthesis of potent and selective kinase inhibitors.
• Asymmetric Synthesis: Utilized in stereoselective synthesis routes to introduce complex molecular architecture with defined chirality.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs supporting outsourced drug development projects.

Basic Information

Product Name	(1S,2R)-2'-Oxospiro[Cyclopropane-1,3'-Indoline]-2-Carbonitrile
CAS No.	895576-37-1
Molecular Formula	C12H10N2O
Molecular Weight	198.22 g/mol
Synonyms	(1S,2R)-2-Cyano-2'-oxospiro[cyclopropane-1,3'-indoline]; (1S,2R)-2-Cyano-2,3-dihydrospiro[cyclopropane-1,3'-indol]-2'-one; 2'-Oxospiro[cyclopropane-1,3'-indoline]-2-carbonitrile, (1S,2R)-; Spiro[cyclopropane-1,3'-indoline]-2'-one, 2-cyano-, (1S,2R)-; (1S,2R)-2-Cyano-1',2'-dihydrospiro[cyclopropane-1,3'-indol]-2'-one; (1S,2R)-2-Cyano-2,3-dihydro-1H-spiro[cyclopropane-1,3'-indol]-2'-one; (1S,2R)-2-Cyano-2'-oxo-1',2'-dihydrospiro[cyclopropane-1,3'-indole]
EINECS	Contact for details

Quality Control

Our (1S,2R)-2'-Oxospiro[Cyclopropane-1,3'-Indoline]-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial methods for identity and assay, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.