Description

1H-Benzimidazole-1-Carboxylic Acid, 6-Fluoro-4-Iodo-, 1,1-Dimethylethyl Ester is a high-value, multi-functional chemical intermediate designed for advanced synthesis. Its core value lies in its unique halogenated benzimidazole structure, which is critical for introducing specific pharmacophores and modifying molecular properties in target compounds. This product is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine-tuning the biological activity of candidate molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those targeting kinase inhibition or requiring halogenated heterocycles for enhanced binding and metabolic stability.
• Agrochemical Synthesis: Used in the development of advanced fungicides and herbicides, where the fluorine and iodine substituents contribute to improved efficacy and environmental profile.
• Material Science Research: Serves as a precursor for creating specialized ligands, catalysts, or monomers used in advanced polymeric materials and organic electronics.
• Chemical Biology & Proteomics: Employed in the design of activity-based probes (ABPs) or affinity tags to study enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring precise, multi-step functionalization on a benzimidazole core.

Basic Information

Product Name	1H-Benzimidazole-1-Carboxylic Acid, 6-Fluoro-4-Iodo-, 1,1-Dimethylethyl Ester
CAS No.	895535-15-6
Molecular Formula	C13H14FIN2O2
Molecular Weight	376.17 g/mol
Synonyms	tert-Butyl 6-fluoro-4-iodo-1H-benzimidazole-1-carboxylate; 6-Fluoro-4-iodo-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester; 6-Fluoro-4-iodobenzimidazole-1-carboxylic acid tert-butyl ester; Boc-6-Fluoro-4-iodobenzimidazole; 895535-15-6; tert-Butyl 6-fluoro-4-iodobenzimidazole-1-carboxylate
EINECS	Contact for details

Quality Control

Our production of 1H-Benzimidazole-1-Carboxylic Acid, 6-Fluoro-4-Iodo-, 1,1-Dimethylethyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to supply chain integrity and batch-to-batch reproducibility makes us a reliable partner for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.