Description

6-Bromo-5-Fluoroindolin-2-One is a high-purity fluorinated and brominated indolinone derivative, serving as a critical building block in advanced organic synthesis. Its unique halogenated structure makes it an indispensable intermediate for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs). This compound is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor and other targeted therapy programs.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization due to its halogen-substituted indole scaffold.
• Chemical Biology Probes: Serves as a precursor for synthesizing molecular probes to study enzyme function and biological pathways.
• Agrochemical Synthesis: Potential intermediate in the development of advanced, high-performance crop protection agents.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced organic electronic materials.

Basic Information

Product Name	6-Bromo-5-Fluoroindolin-2-One
CAS No.	893620-44-5
Molecular Formula	C8H5BrFNO
Molecular Weight	230.04 g/mol
Synonyms	6-Bromo-5-fluoro-2,3-dihydro-1H-indol-2-one; 5-Fluoro-6-bromoindolin-2-one; 2-Indolinone, 6-bromo-5-fluoro-; 6-Bromo-5-fluoro-1,3-dihydro-2H-indol-2-one; 6-Bromo-5-fluorooxindole
EINECS	Contact for details

Quality Control

Our 6-Bromo-5-Fluoroindolin-2-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.