Description

tert-Butyl 8-Bromo-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a brominated isoquinoline core protected by a tert-butoxycarbonyl (Boc) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical, biotechnology, and fine chemical companies engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially those targeting protein kinases and other enzymatic pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the bromine atom for further functionalization via cross-coupling reactions.
• API Development: Serves as a critical scaffold in the development of Active Pharmaceutical Ingredients (APIs) with potential anticancer or neuropharmacological activity.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying biological processes and target identification.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• Library Synthesis: Used in combinatorial chemistry to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	tert-Butyl 8-Bromo-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	893566-75-1
Molecular Formula	C14H16BrNO2
Molecular Weight	310.19 g/mol
Synonyms	8-Bromo-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 2-Boc-8-bromo-1,2,3,4-tetrahydroisoquinoline; tert-Butyl 8-bromo-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 8-Bromo-2-N-Boc-1,2,3,4-tetrahydroisoquinoline; Boc-8-Bromo-THIQ; 893566-75-1; 8-Bromo-THIQ-Boc
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Bromo-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.