Description

6-Bromo-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is a high-value, protected heterocyclic building block essential for modern pharmaceutical and agrochemical research. This compound serves as a critical intermediate in the synthesis of complex molecules, offering a versatile scaffold for the introduction of the isoquinoline pharmacophore. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactive isoquinoline core.
• Chemical Biology & Proteomics: Serves as a precursor for designing molecular probes and activity-based protein profiling (ABPP) reagents.
• Material Science: Potential monomer or precursor for advanced organic electronic materials and specialty polymers.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and exploratory synthesis.
• Custom Synthesis & Scale-Up: Foundation for the custom manufacturing of complex, bromine-functionalized isoquinoline derivatives under GMP or non-GMP conditions.

Basic Information

Product Name	6-Bromo-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester
CAS No.	893566-74-0
Molecular Formula	C14H16BrNO2
Molecular Weight	310.19 g/mol
Synonyms	tert-Butyl 6-bromo-3,4-dihydro-1H-isoquinoline-2-carboxylate; 6-Bromo-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 2-Boc-6-bromo-1,2,3,4-tetrahydroisoquinoline; 6-Bromo-2-N-Boc-1,2,3,4-tetrahydroisoquinoline; 6-Bromo-THIQ-2-Boc; Boc-6-Bromo-THIQ; 893566-74-0; 6-Bromo-3,4-dihydro-2H-isoquinoline-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Every batch of 6-Bromo-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.