Description

1-Boc-Indole-4-Boronic Acid Pinacol Ester is a high-purity, protected boronic ester derivative, a crucial advanced intermediate in modern synthetic chemistry. Its core value lies in enabling efficient, selective cross-coupling reactions, particularly Suzuki-Miyaura couplings, for constructing complex heterocyclic scaffolds. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical research, and material science, where it serves as a key building block for active pharmaceutical ingredients (APIs) and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Suzuki-Miyaura Cross-Coupling: Protected boronic ester reagent for palladium-catalyzed carbon-carbon bond formation under mild conditions.
• Agrochemical Research: Intermediate for developing new crop protection agents and herbicides with complex heterocyclic structures.
• Material Science & OLED Development: Precursor for creating organic electronic materials and emissive layers in display technologies.
• Chemical Biology & Proteolysis-Targeting Chimeras (PROTACs): Used in the construction of bifunctional molecules for targeted protein degradation.
• Academic & Contract Research: Versatile reagent for methodology development and library synthesis in medicinal chemistry programs.

Basic Information

Product Name	1-Boc-Indole-4-Boronic Acid Pinacol Ester
CAS No.	893441-86-6
Molecular Formula	C19H26BNO4
Molecular Weight	343.23 g/mol
Synonyms	1-Boc-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 1-(tert-Butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 4-Borono-1H-indole-1-carboxylic acid, 1,1-dimethylethyl ester, pinacol ester; tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate; 1-Boc-4-Bpin-indole; 1-Boc-indole-4-Bpin; BOC-Indole-4-Boronic Acid Pinacol Ester
EINECS	Contact for details

Quality Control

Our 1-Boc-Indole-4-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and production. Each lot is characterized by NMR (1H, 13C), HPLC, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) with full analytical data are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a dry environment to maintain stability. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.