Description

2-Methyl-4-(Difluoromethyl)-1,3-Thiazole-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique thiazole core and difluoromethyl substituent. This compound is essential for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of agrochemicals and life science products where fluorine incorporation is critical for enhancing metabolic stability and bioavailability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in antiviral, anti-inflammatory, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Serves as a critical precursor in the development of next-generation fungicides, herbicides, and insecticides, leveraging the bioactivity of the thiazole ring.
• Chemical Research & Development: Used in academic and industrial R&D for exploring new chemical entities and structure-activity relationships (SAR).
• Material Science: Potential intermediate for the synthesis of specialty chemicals, ligands, or functional materials requiring fluorinated heterocycles.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial production of fluorinated target molecules.

Basic Information

Product Name	2-Methyl-4-(Difluoromethyl)-1,3-Thiazole-5-Carboxylic Acid
CAS No.	891487-47-1
Molecular Formula	C6H5F2NO2S
Molecular Weight	193.17 g/mol
Synonyms	2-Methyl-4-(difluoromethyl)-1,3-thiazole-5-carboxylic acid; 5-Thiazolecarboxylic acid, 2-methyl-4-(difluoromethyl)-; 4-(Difluoromethyl)-2-methyl-1,3-thiazole-5-carboxylic Acid; 2-Methyl-4-difluoromethyl-thiazole-5-carboxylic acid; DFMT-CA; CAS 891487-47-1
EINECS	Contact for details

Quality Control

Our production of 2-Methyl-4-(Difluoromethyl)-1,3-Thiazole-5-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Every lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR) against established internal specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container must be kept tightly closed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.