Description

(S)-2-Methyl-3,5-Dioxo-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester CAS NO 890709-66-7 is a high-purity chiral building block and protected amino acid derivative essential for advanced organic synthesis. This compound is critical for the development of novel pharmaceuticals and bioactive molecules, offering a versatile scaffold for constructing complex, stereochemically defined structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of active pharmaceutical ingredients (APIs), peptidomimetics, and other fine chemicals where precise stereochemistry is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new Active Pharmaceutical Ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder treatments.
• Peptidomimetic Synthesis: Serves as a protected proline or glutamic acid analog for constructing peptide-like molecules with enhanced stability and bioavailability.
• Asymmetric Catalysis Ligand Precursor: Used in the preparation of chiral ligands and organocatalysts for enantioselective synthesis.
• Protease Inhibitor Development: Acts as a core structural element in the design of inhibitors for various enzymes like proteases and kinases.
• Chemical Biology Research: Employed as a molecular probe or building block in medicinal chemistry for structure-activity relationship (SAR) studies.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis services catering to the fine chemical and agrochemical industries.

Basic Information

Product Name	(S)-2-Methyl-3,5-Dioxo-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	890709-66-7
Molecular Formula	C10H15NO5
Molecular Weight	229.23 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)-2-methyl-3,5-pyrrolidinedione; (S)-1-Boc-2-methyl-3,5-pyrrolidinedione; (S)-2-Methyl-1-Boc-3,5-pyrrolidinedione; (S)-2-Methyl-1-(tert-butoxycarbonyl)pyrrolidine-3,5-dione; tert-Butyl (S)-2-methyl-3,5-dioxopyrrolidine-1-carboxylate; (S)-Boc-2-methyl-3,5-pyrrolidinedione; (S)-N-Boc-2-methyl-3,5-pyrrolidinedione; (S)-2-Methyl-3,5-dioxo-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our (S)-2-Methyl-3,5-Dioxo-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.