Description

tert-Butyl n-Succinimidyl N,N'-Trimethylenedicarbamate is a specialized bifunctional cross-linking reagent designed for the controlled conjugation of biomolecules. This compound matters because it provides a stable, cleavable linker with orthogonal reactivity, enabling precise bioconjugation strategies in advanced research and development. It is primarily needed by pharmaceutical researchers and biotech companies engaged in the development of antibody-drug conjugates (ADCs), peptide synthesis, and protein modification.

Application

• Key reagent in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Cross-linking agent for protein-protein conjugation and immobilization studies.
• Intermediate in the preparation of peptide-based prodrugs and drug delivery systems.
• Functionalization of solid supports and surfaces for biosensor development.
• Tool compound for bioconjugation chemistry in academic and industrial R&D.
• Building block for creating cleavable linkers in chemical biology probes.

Basic Information

Product Name	tert-Butyl n-Succinimidyl N,N'-Trimethylenedicarbamate
CAS No.	890091-52-8
Molecular Formula	C15H23N3O6
Molecular Weight	341.36 g/mol
Synonyms	1,3-Bis[(tert-butoxycarbonyl)amino]propyl N-succinimidyl dicarbonate; N,N'-Bis(Boc)-1,3-diaminopropane NHS ester; Boc-NH-(CH2)3-NH-Boc NHS ester; BOC2-1,3-diaminopropane NHS ester; tert-Butyl N-(3-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonylamino]propyl)carbamate; BOC-protected diaminopropane NHS crosslinker; 1,3-Diaminopropane, N,N'-bis(tert-butoxycarbonyl)-, N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Our tert-Butyl n-Succinimidyl N,N'-Trimethylenedicarbamate is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and specifications are designed to meet the stringent requirements of bioconjugation and pharmaceutical intermediate use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.