Description

(S)-2,2,2-Trifluoro-1-(4-Fluorophenyl)Ethanol is a high-value chiral fluorinated building block essential for modern asymmetric synthesis. This compound matters because its unique stereochemistry and fluorine substitution pattern make it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecules with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure drugs, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides where the fluorine atoms and chiral center improve biological activity and environmental profile.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric hydrogenation and carbon-carbon bond-forming reactions.
• Material Science Research: Employed in the synthesis of fluorinated liquid crystals and polymers with specific optical and electronic properties.
• Process Chemistry & Scale-up: Utilized in route scouting and optimization for the commercial manufacturing of fluorinated target molecules.

Basic Information

Product Name	(S)-2,2,2-Trifluoro-1-(4-Fluorophenyl)Ethanol
CAS No.	890085-08-2
Molecular Formula	C8H6F4O
Molecular Weight	194.13 g/mol
Synonyms	(S)-α-(Trifluoromethyl)-4-fluorobenzyl alcohol; (S)-1-(4-Fluorophenyl)-2,2,2-trifluoroethanol; (S)-2,2,2-Trifluoro-1-(4-fluorophenyl)ethan-1-ol; (S)-4-Fluoro-α-(trifluoromethyl)benzenemethanol; (S)-F-PTFM; (S)-F-TFE; (S)-F-PTFEA; (S)-Enantiomer of 1-(4-Fluorophenyl)-2,2,2-trifluoroethanol
EINECS	Contact for details

Quality Control

Our (S)-2,2,2-Trifluoro-1-(4-Fluorophenyl)Ethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and chiral purity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.