Description

3-Hydroxy-6,6-Dimethyl-1-Oxo-1,2,5,6,7,8-Hexahydroisoquinoline-4-Carbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is critical for research and development in medicinal chemistry, serving as a versatile building block for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in drug discovery programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug candidates, particularly those with isoquinoline or tetrahydroisoquinoline scaffolds.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• API Synthesis: Used in multi-step synthetic routes for the production of potential therapeutic agents, including central nervous system (CNS) and anti-infective drugs.
• Chemical Biology Probes: Utilized in the development of molecular probes to study biological pathways and enzyme functions.
• Fine Chemical Manufacturing: Employed in the custom synthesis of specialty chemicals for advanced material science and agrochemical research.

Basic Information

Product Name	3-Hydroxy-6,6-Dimethyl-1-Oxo-1,2,5,6,7,8-Hexahydroisoquinoline-4-Carbonitrile
CAS No.	890023-13-9
Molecular Formula	C₁₂H₁₄N₂O₂
Molecular Weight	218.25 g/mol
Synonyms	3-Hydroxy-6,6-dimethyl-1-oxo-1,2,5,6,7,8-hexahydroisoquinoline-4-carbonitrile; 4-Cyano-3-hydroxy-6,6-dimethyl-1,2,5,6,7,8-hexahydroisoquinolin-1-one; 6,6-Dimethyl-1-oxo-1,2,5,6,7,8-hexahydroisoquinoline-3-ol-4-carbonitrile; 890023-13-9; Hexahydroisoquinoline-4-carbonitrile derivative
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-6,6-Dimethyl-1-Oxo-1,2,5,6,7,8-Hexahydroisoquinoline-4-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports compliance with cGMP standards for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.