Description

3-Acetyl-n-Triisopropylsilyl Indole is a high-value, protected indole derivative used as a key synthetic intermediate in advanced organic chemistry. This compound is critical for researchers and manufacturers requiring precise control over indole nitrogen reactivity in multi-step synthesis. It is primarily utilized in the development of pharmaceuticals, agrochemicals, and novel materials where the triisopropylsilyl (TIPS) group provides steric protection and selective deprotection capabilities.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of complex indole-based drug candidates, including kinase inhibitors and serotonin receptor modulators.
• Agrochemical Research: Used in the development of new fungicides and plant growth regulators that leverage the indole scaffold.
• Material Science: Serves as a precursor for organic semiconductors and advanced polymers requiring functionalized indole units.
• Academic & R&D: A valuable reagent for methodological studies in organic synthesis, particularly in palladium-catalyzed cross-coupling and C-H functionalization reactions.
• Fine Chemical Synthesis: Employed in the production of specialty chemicals, dyes, and fragrances where protected indole intermediates are necessary.

Basic Information

Item	Details
Product Name	3-Acetyl-n-Triisopropylsilyl Indole
CAS No.	889939-11-1
Molecular Formula	C20H31NOSi
Molecular Weight	329.56 g/mol
Synonyms	1-(1-((Triisopropylsilyl)indol-3-yl)ethanone; 3-Acetyl-1-(triisopropylsilyl)-1H-indole; N-Triisopropylsilyl-3-acetylindole; 3-Acetylindole, N-TIPS protected; TIPS-3-acetylindole; 1H-Indole, 3-acetyl-1-[(1,1-dimethylethyl)dimethylsilyl]-; 3-Acetyl-1-triisopropylsilylindole
EINECS	Contact for details

Quality Control

Our 3-Acetyl-n-Triisopropylsilyl Indole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.