Description

Ethyl 5-Fluoro-3-Oxo-2,3-Dihydro-1H-Indazole-1-Carboxylate is a high-value fluorinated indazole derivative, serving as a critical synthetic intermediate in modern pharmaceutical research and development. Its core value lies in providing a versatile scaffold for constructing novel bioactive molecules, particularly in the areas of kinase inhibition and targeted cancer therapies. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-purity building blocks for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly kinase inhibitors and other targeted small-molecule therapeutics.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization processes due to its versatile indazole core and fluorine substituent.
• API (Active Pharmaceutical Ingredient) Development: Serves as a precursor in the multi-step synthesis of complex active pharmaceutical ingredients under current Good Manufacturing Practice (cGMP) conditions.
• Biochemical Tool Compound: Employed in the development of biochemical probes and assay standards for high-throughput screening and target validation.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for the production of specialized fluorinated heterocycles.

Basic Information

Product Name	Ethyl 5-Fluoro-3-Oxo-2,3-Dihydro-1H-Indazole-1-Carboxylate
CAS No.	889884-99-5
Molecular Formula	C10H9FN2O3
Molecular Weight	224.19 g/mol
Synonyms	1H-Indazole-1-carboxylic acid, 5-fluoro-2,3-dihydro-3-oxo-, ethyl ester; Ethyl 5-fluoro-3-oxo-2,3-dihydroindazole-1-carboxylate; 5-Fluoro-1H-indazole-1-carboxylic acid ethyl ester, 2,3-dihydro-3-oxo-; 889884-99-5; Ethyl 5-fluoro-3-oxo-2,3-dihydro-1H-indazole-1-carboxylate; 1-Carbethoxy-5-fluoro-3-hydroxy-1H-indazole
EINECS	Contact for details

Quality Control

Our Ethyl 5-Fluoro-3-Oxo-2,3-Dihydro-1H-Indazole-1-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support customer requirements from early-stage research through to pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and stored away from direct light and moisture sources to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Any individual impurity ≤ 0.5% Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.