Description

Spiro[Isoquinoline-4(4H),4'-Piperidine]-2(3H)-Carboxylic Acid 1,1-Dimethylethyl Ester Monohydrochloride is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery. This compound serves as a critical building block for the synthesis of complex molecules targeting central nervous system (CNS) disorders. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within the fields of neurology and psychiatry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for neurological and psychiatric medications.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in CNS-targeted programs.
• Chemical Biology: Employed as a molecular scaffold or probe in biochemical assays to study receptor-ligand interactions.
• Process Development: Serves as a standard or reference material for scaling up and validating synthetic routes in pilot and commercial manufacturing.
• Academic Research: Utilized in university and institutional labs for investigating new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	Spiro[Isoquinoline-4(4H),4'-Piperidine]-2(3H)-Carboxylic Acid 1,1-Dimethylethyl Ester Monohydrochloride
CAS No.	889139-52-0
Molecular Formula	C19H26N2O2·HCl
Molecular Weight	350.89 g/mol
Synonyms	tert-Butyl 2-oxo-1,4-dihydrospiro[isoquinoline-4,4'-piperidine]-1-carboxylate hydrochloride; 1,1-Dimethylethyl 2,3-dihydro-2-oxospiro[4H-isoquinoline-4,4'-piperidine]-1-carboxylate hydrochloride; Spiro[isoquinoline-4(1H),4'-piperidine]-1-carboxylic acid, 2,3-dihydro-2-oxo-, 1,1-dimethylethyl ester, hydrochloride; BOC-Spiro[isoquinoline-4(1H),4'-piperidine]-2-one hydrochloride; tert-Butyl 2-oxospiro[isoquinoline-4(4H),4'-piperidine]-1(2H)-carboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our Spiro[Isoquinoline-4(4H),4'-Piperidine]-2(3H)-Carboxylic Acid 1,1-Dimethylethyl Ester Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.