Description

3-Aminomethyl-Thiophene-2-Carboxylic Acid tert-Butyl Ester is a high-value, protected amino acid derivative that serves as a critical building block in advanced organic synthesis. Its bifunctional structure, featuring both a protected amine and a carboxylic acid ester, makes it an essential intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and active ingredient development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of thiophene-based drug candidates.
• Peptidomimetics & Bioactive Molecule Synthesis: Used to incorporate thiophene scaffolds and modified amino acid residues into peptides and other bioactive compounds.
• Agrochemical Research: Intermediate in the development of new herbicides, fungicides, and insecticides that utilize heterocyclic chemistry.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal complexation.
• Material Science: Potential monomer or precursor for functional polymers and advanced organic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for custom synthesis projects and scale-up activities.

Basic Information

Product Name	3-Aminomethyl-Thiophene-2-Carboxylic Acid tert-Butyl Ester
CAS No.	887594-90-3
Molecular Formula	C11H17NO2S
Molecular Weight	227.32 g/mol
Synonyms	tert-Butyl 3-(aminomethyl)thiophene-2-carboxylate; 2-Thiophenecarboxylic acid, 3-(aminomethyl)-, 1,1-dimethylethyl ester; 3-(Aminomethyl)thiophene-2-carboxylic acid tert-butyl ester; 3-Carbamoylmethyl-thiophene-2-carboxylic acid tert-butyl ester (common misnomer); Boc-protected 3-aminomethylthiophene-2-carboxylic acid (analogous naming); (3-Aminomethyl-thiophen-2-yl)-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of 3-Aminomethyl-Thiophene-2-Carboxylic Acid tert-Butyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize degradation. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.