Description

(1,2,3,4-Tetrahydro-Isoquinolin-5-Yl)-Carbamic Acid tert-Butyl Ester is a high-purity, protected amine derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its primary value lies in enabling the controlled introduction of the 1,2,3,4-tetrahydroisoquinoline scaffold, a privileged structure in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and oncology.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that incorporate the tetrahydroisoquinoline moiety.
• Organic Synthesis: Serves as a versatile protected amine precursor for constructing complex heterocyclic compounds and natural product analogs.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, enzyme inhibitors, and activity-based protein profiling (ABPP) reagents.
• Material Science: Potential intermediate for creating specialty polymers, ligands for catalysis, and advanced organic electronic materials.

Basic Information

Product Name	(1,2,3,4-Tetrahydro-Isoquinolin-5-Yl)-Carbamic Acid tert-Butyl Ester
CAS No.	887591-04-0
Molecular Formula	C₁₄H₂₀N₂O₂
Molecular Weight	248.32 g/mol
Synonyms	5-[(tert-Butoxycarbonyl)amino]-1,2,3,4-tetrahydroisoquinoline; N-Boc-5-amino-1,2,3,4-tetrahydroisoquinoline; tert-Butyl (1,2,3,4-tetrahydroisoquinolin-5-yl)carbamate; Boc-5-ATIQ; 5-Amino-1,2,3,4-tetrahydroisoquinoline N-Boc derivative; 5-N-Boc-amino-1,2,3,4-tetrahydroisoquinoline; (5-Tetrahydroisoquinolinyl)carbamic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our (1,2,3,4-Tetrahydro-Isoquinolin-5-Yl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.