Description

3-(5-Iodothiophen-2-Yl)-3-Oxopropanenitrile is a specialized organic building block featuring a reactive cyanoacetyl group attached to an iodinated thiophene ring. This compound matters for its unique molecular architecture, which serves as a versatile synthon in modern heterocyclic and pharmaceutical chemistry. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing functionalized thiophene cores.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that leverage the iodine atom for further functionalization.
• Material Science: Serves as a monomer or building block for creating conjugated polymers and organic electronic materials with specific optoelectronic properties.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form complex biaryl systems.
• Ligand Synthesis: Utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Acts as a starting point for synthesizing molecular probes and tags for studying biological systems.

Basic Information

Product Name	3-(5-Iodothiophen-2-Yl)-3-Oxopropanenitrile
CAS No.	887588-22-9
Molecular Formula	C7H4INOS
Molecular Weight	276.08 g/mol
Synonyms	3-(5-Iodo-2-thienyl)-3-oxopropanenitrile; 2-(Cyanomethyl)-5-iodothiophene-3-one; 5-Iodo-2-thienyl cyanomethyl ketone; 3-Oxo-3-(5-iodothiophen-2-yl)propanenitrile; 5-Iodo-2-thiophenecarbonylacetonitrile; (5-Iodothiophen-2-yl)(cyano)methyl ketone; 3-(5-Iodo-thiophen-2-yl)-3-oxo-propionitrile
EINECS	Contact for details

Quality Control

Our 3-(5-Iodothiophen-2-Yl)-3-Oxopropanenitrile is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere for prolonged procedures to ensure stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.