Description

1-Cyclohexyl-3-(tert-Butyldimethylsilyl)-2-Propyn-1-Ol is a specialized organosilicon-protected propargylic alcohol intermediate of significant synthetic utility. This compound matters for its role as a versatile building block in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications in medicinal chemistry and fine chemical production.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of novel drug candidates, particularly in creating complex alkyne-containing scaffolds.
• Agrochemical Synthesis: Used in the research and development of new active ingredients for crop protection products.
• Material Science Research: Serves as a precursor for functionalized polymers or advanced organic materials requiring specific alkyne functionalities.
• Cross-Coupling Reactions: Acts as a substrate in Sonogashira and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Natural Product Synthesis: Employed in the total synthesis of complex natural products where the protected propargylic alcohol moiety is required.
• Ligand and Catalyst Development: Useful for preparing novel chiral ligands or organometallic catalysts for asymmetric synthesis.

Basic Information

Product Name	1-Cyclohexyl-3-(tert-Butyldimethylsilyl)-2-Propyn-1-Ol
CAS No.	887586-33-6
Molecular Formula	C15H28OSi
Molecular Weight	252.47 g/mol
Synonyms	1-Cyclohexyl-3-[(1,1-dimethylethyl)dimethylsilyl]-2-propyn-1-ol; 1-Cyclohexyl-3-(TBDMS)-2-propyn-1-ol; 3-(tert-Butyldimethylsilyl)-1-cyclohexyl-2-propyn-1-ol; TBDMS-protected Cyclohexyl Propargyl Alcohol; Cyclohexyl(tert-butyldimethylsilyl)propargyl alcohol; 1-Cyclohexyl-3-(tert-butyldimethylsiloxy)-1-propyne; (1-Cyclohexyl-2-propyn-1-yloxy)(tert-butyl)dimethylsilane
EINECS	Contact for details

Quality Control

Our 1-Cyclohexyl-3-(tert-Butyldimethylsilyl)-2-Propyn-1-Ol is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.