Description

4-Chloro-6-Nitro-3-(1H)Indazole Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a distinct molecular structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and targeted therapy research. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex indazole-based drug candidates.
• Oncology Research: Used in the development of kinase inhibitors and other targeted cancer therapies.
• Chemical Biology: Serves as a versatile scaffold for creating molecular probes and bio-conjugates.
• Agrochemical Development: Potential intermediate for creating novel herbicides and plant growth regulators.
• Material Science: Research into organic electronic materials and metal-organic frameworks (MOFs).
• Contract Manufacturing: Supplied to CDMOs for custom synthesis and scale-up projects under cGMP conditions.

Basic Information

Product Name	4-Chloro-6-Nitro-3-(1H)Indazole Carboxylic Acid
CAS No.	887570-79-8
Molecular Formula	C8H4ClN3O4
Molecular Weight	241.59 g/mol
Synonyms	4-Chloro-6-nitro-1H-indazole-3-carboxylic acid; 4-Chloro-6-nitroindazole-3-carboxylic acid; 3-Carboxy-4-chloro-6-nitroindazole; 1H-Indazole-3-carboxylic acid, 4-chloro-6-nitro-; 887570-79-8; 4-Chloro-6-nitro-1H-indazole-3-carboxylic acid; 4-Cl-6-NO2-1H-indazole-3-COOH
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-Nitro-3-(1H)Indazole Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to cGMP guidelines for pharmaceutical applications upon request, ensuring traceability and regulatory compliance for advanced research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.