Description

2,2-Dimethyl-3-(4-Mercaptophenyl)Propionic Acid CAS NO 887354-80-5 is a specialized organic compound featuring both a carboxylic acid and a thiol (mercapto) functional group on an aromatic ring. This unique bifunctional structure makes it a valuable intermediate for synthesizing complex molecules, particularly in the pharmaceutical and advanced materials sectors. It is primarily sought after by research chemists and process development scientists working on novel drug candidates, peptide mimetics, and functional polymers.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting cysteine protease enzymes or requiring thiol conjugation.
• Peptide Chemistry: Used in the preparation of modified amino acids and peptide derivatives where the thiol group enables selective coupling or disulfide bridge formation.
• Polymer Modification: Serves as a functional monomer or cross-linking agent for creating specialty polymers with tailored properties like adhesion or reactivity.
• Ligand Synthesis: Employed in the development of chelating agents and catalysts for organic synthesis and metal recovery processes.
• Bioconjugation: Facilitates the attachment of drugs, dyes, or other molecules to proteins, antibodies, or nanoparticles via thiol-maleimide or disulfide chemistry.
• Material Science Research: Investigated for creating self-assembled monolayers (SAMs) on gold surfaces and other advanced material applications.

Basic Information

Product Name	2,2-Dimethyl-3-(4-Mercaptophenyl)Propionic Acid
CAS No.	887354-80-5
Molecular Formula	C11H14O2S
Molecular Weight	210.29 g/mol
Synonyms	4-(2-Carboxy-2-methylpropyl)benzenethiol; 3-(4-Mercaptophenyl)-2,2-dimethylpropanoic Acid; 2,2-Dimethyl-3-(4-sulfanylphenyl)propanoic Acid; 4-(2,2-Dimethyl-3-carboxypropyl)thiophenol; p-(2-Carboxy-2-methylpropyl)thiophenol; 4-(2,2-Dimethyl-3-carboxypropyl)benzenethiol; 3-(4-Thiolphenyl)-2,2-dimethylpropionic Acid
EINECS	Contact for details

Quality Control

Our 2,2-Dimethyl-3-(4-Mercaptophenyl)Propionic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation of the thiol group and ensure long-term stability. Keep the container in a cool, dry, and well-ventilated area, separate from oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.