Description

2-Benzyloxy-5-Nitrobenzenethiol is a specialized aromatic thiol derivative characterized by its benzyl-protected phenolic oxygen and nitro-substituted aromatic ring. This compound is a valuable synthetic intermediate, offering a unique combination of a protected thiol group and an electron-withdrawing nitro substituent, which is crucial for constructing complex molecular architectures. It is primarily required by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in organic synthesis, ligand development, and as a building block for heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing sulfur-based pharmacophores.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides where the nitro and thiol functionalities are integral to biological activity.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for metal catalysis and coordination chemistry due to the presence of the thiol group.
• Polymer and Material Science: Acts as a monomer or functionalization agent in the creation of specialty polymers, resins, and advanced materials with tailored properties.
• Organic Synthesis Building Block: Utilized in various name reactions, including nucleophilic aromatic substitution (SNAr) and palladium-catalyzed cross-couplings, to introduce functionalized arylthio groups.
• Chemical Research: A fundamental reagent in academic and industrial R&D laboratories for exploring new synthetic methodologies and reaction pathways.

Basic Information

Product Name	2-Benzyloxy-5-Nitrobenzenethiol
CAS No.	887353-11-9
Molecular Formula	C₁₃H₁₁NO₃S
Molecular Weight	261.30 g/mol
Synonyms	5-Nitro-2-(phenylmethoxy)benzenethiol; 2-(Benzyloxy)-5-nitrobenzenethiol; 2-Benzyloxy-5-nitrothiophenol; 1-Benzyloxy-2-nitro-4-mercaptobenzene; Benzenethiol, 2-(benzyloxy)-5-nitro-; 2-(Benzyloxy)-5-nitrobenzene-1-thiol
EINECS	Contact for details

Quality Control

Our 2-Benzyloxy-5-Nitrobenzenethiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR), to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to handle and store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation of quality. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.