Description

Ethyl 2-Amino-4-(2,5-Difluoro)Phenyl Thiazole-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its distinct thiazole core and difluorophenyl substitution. This compound is of significant commercial value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Research: Serves as a key synthon for developing new generation herbicides, fungicides, and insecticides that leverage the bioactivity of the thiazole moiety.
• Material Science Chemistry: Used in the research and development of organic electronic materials, such as OLEDs and semiconductors, where fluorinated aromatic systems are advantageous.
• Chemical Biology & Proteomics: Employed as a scaffold or linker in the design of chemical probes and enzyme inhibitors for biochemical research.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global pharmaceutical clients.

Basic Information

Product Name	Ethyl 2-Amino-4-(2,5-Difluoro)Phenyl Thiazole-5-Carboxylate
CAS No.	887267-76-7
Molecular Formula	C12H10F2N2O2S
Molecular Weight	284.28 g/mol
Synonyms	5-Thiazolecarboxylic acid, 2-amino-4-(2,5-difluorophenyl)-, ethyl ester; Ethyl 2-amino-4-(2,5-difluorophenyl)-1,3-thiazole-5-carboxylate; 2-Amino-4-(2,5-difluorophenyl)thiazole-5-carboxylic acid ethyl ester; 4-(2,5-Difluorophenyl)-2-aminothiazole-5-carboxylic acid ethyl ester; 887267-76-7; Ethyl 2-Amino-4-(2,5-Difluorophenyl)-5-thiazolecarboxylate
EINECS	Contact for details

Quality Control

Every batch of Ethyl 2-Amino-4-(2,5-Difluoro)Phenyl Thiazole-5-Carboxylate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the stringent requirements of pharmaceutical R&D and scale-up. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.