Description

Ethyl 2-Amino-4-(4-(Trifluoromethyl)Phenyl)Thiazole-5-Carboxylate is a high-value, multi-functional heterocyclic building block featuring a thiazole core substituted with a trifluoromethylphenyl group. This compound is critical for research and development in advanced organic synthesis, offering a versatile scaffold for creating novel molecules with tailored properties. It is primarily sought after by pharmaceutical, agrochemical, and material science industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly for targets where the trifluoromethyl group can enhance metabolic stability and bioavailability.
• Agrochemical Research: Used in developing new herbicides, fungicides, and insecticides, leveraging the biological activity of the thiazole moiety.
• Material Science: Acts as a building block for advanced organic materials, such as organic semiconductors, liquid crystals, or polymers with specific electronic properties.
• Chemical Biology & Proteomics: Employed as a scaffold or linker in the design of chemical probes and inhibitors for studying biological pathways.
• Academic & Contract Research: Essential for synthetic chemistry research in universities and CROs exploring novel heterocyclic chemistry and structure-activity relationships.

Basic Information

Product Name	Ethyl 2-Amino-4-(4-(Trifluoromethyl)Phenyl)Thiazole-5-Carboxylate
CAS No.	887267-75-6
Molecular Formula	C13H11F3N2O2S
Molecular Weight	316.30 g/mol
Synonyms	Ethyl 2-Amino-4-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylate; 5-Carbethoxy-2-amino-4-(4-trifluoromethylphenyl)thiazole; 2-Amino-4-(4-trifluoromethylphenyl)thiazole-5-carboxylic acid ethyl ester; 4-(4-(Trifluoromethyl)phenyl)-2-aminothiazole-5-carboxylic acid ethyl ester; ATFC; 887267-75-6
EINECS	Contact for details

Quality Control

Our production of Ethyl 2-Amino-4-(4-(Trifluoromethyl)Phenyl)Thiazole-5-Carboxylate adheres to stringent in-process controls and final batch analysis to ensure consistent high purity and reliable performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to support cGMP and ISO standards for traceability and documentation, meeting the rigorous demands of global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed and may require storage under an inert atmosphere or with desiccant for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.