Description

4-(2,2,2-Trifluoroethoxy)Phenylboronic Acid Pinacol Ester is a high-value, protected boronic acid derivative essential for modern synthetic chemistry, particularly in cross-coupling reactions. Its core value lies in providing a stable, reactive handle for the controlled introduction of the 4-(2,2,2-trifluoroethoxy)phenyl moiety into complex molecular architectures. This compound is critically needed by R&D and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where the trifluoroethoxy group can significantly influence a molecule's metabolic stability, lipophilicity, and binding affinity.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-couplings for synthesizing potential drug candidates, especially those targeting CNS disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used to incorporate the trifluoroethoxy-phenyl group into novel herbicides, fungicides, and insecticides to enhance their efficacy and environmental profile.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced organic electronic materials, such as OLEDs and semiconductors.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for catalysis or as a precursor for boron-containing molecular scaffolds.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses serving the life sciences sector.

Basic Information

Item	Details
Product Name	4-(2,2,2-Trifluoroethoxy)Phenylboronic Acid Pinacol Ester
CAS No.	886528-42-3
Molecular Formula	C15H20BF3O3
Molecular Weight	316.13 g/mol
Synonyms	4-(2,2,2-Trifluoroethoxy)benzeneboronic acid pinacol ester; [4-(2,2,2-Trifluoroethoxy)phenyl]boronic acid pinacol ester; 2-[4-(2,2,2-Trifluoroethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(Trifluoroethoxy)phenylboronic acid pinacol ester; 4-(2,2,2-Trifluoroethoxy)phenyl-Bpin; B-[4-(2,2,2-Trifluoroethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 4-(2,2,2-Trifluoroethoxy)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.