Description

5-(3-Trifluoromethyl-Phenyl)-Thiophene-2-Carbaldehyde is a high-purity organic building block featuring a thiophene core substituted with a carbaldehyde group and a trifluoromethylphenyl moiety. This compound matters as a versatile and critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs), where the trifluoromethyl group is prized for its ability to modulate lipophilicity and metabolic stability. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Research: Serves as a precursor for organic electronic materials, such as semiconductors and non-linear optical (NLO) materials, due to the electron-rich thiophene unit.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	5-(3-Trifluoromethyl-Phenyl)-Thiophene-2-Carbaldehyde
CAS No.	886508-92-5
Molecular Formula	C12H7F3OS
Molecular Weight	256.24 g/mol
Synonyms	5-[3-(Trifluoromethyl)phenyl]thiophene-2-carboxaldehyde; 5-(3-Trifluoromethylphenyl)-2-thiophenecarboxaldehyde; 5-(3-Trifluoromethylphenyl)thiophene-2-carbaldehyde; 2-Thiophenecarboxaldehyde, 5-[3-(trifluoromethyl)phenyl]-; 886508-92-5; 5-(3-Trifluoromethyl-Phenyl)-Thiophene-2-Carboxaldehyde; 5-(α,α,α-Trifluoro-m-tolyl)thiophene-2-carbaldehyde
EINECS	Contact for details

Quality Control

Our 5-(3-Trifluoromethyl-Phenyl)-Thiophene-2-Carbaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.