Description

5-(3-Hydroxy-3-Methylbut-1-Yn-1-Yl)Thiophene-2-Carboxylic Acid (Saltdata: Free) is a high-purity, advanced pharmaceutical intermediate characterized by its unique molecular architecture combining a thiophene carboxylic acid core with a functionalized alkyne side chain. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) where precise structural control is paramount. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Organic Synthesis Reagent: Used in advanced organic reactions, including Sonogashira coupling and other cross-coupling methodologies, to construct complex molecular frameworks.
• Agrochemical Research: Acts as a precursor in the development of new generation pesticides and herbicides that require specific heterocyclic motifs for bioactivity.
• Material Science: Investigated for use in the synthesis of organic semiconductors and conductive polymers due to the electron-rich thiophene moiety.
• Academic & R&D: Employed in university and corporate research laboratories for methodological studies and the exploration of new chemical spaces.
• Custom Synthesis: Provided as a starting material for contract research organizations (CROs) and CDMOs for client-specific synthetic projects.

Basic Information

Product Name	5-(3-Hydroxy-3-Methylbut-1-Yn-1-Yl)Thiophene-2-Carboxylic Acid (Saltdata: Free)
CAS No.	886505-51-7
Molecular Formula	C11H10O3S
Molecular Weight	222.26 g/mol
Synonyms	5-(3-Hydroxy-3-methylbut-1-yn-1-yl)thiophene-2-carboxylic acid; 2-Thiophenecarboxylic acid, 5-(3-hydroxy-3-methyl-1-butyn-1-yl)-; 5-(3-Hydroxy-3-methylbut-1-ynyl)thiophene-2-carboxylic acid; 5-(3-Hydroxy-3-methylbut-1-yn-1-yl)-2-thiophenecarboxylic acid; 5-(3-Hydroxy-3-methylbut-1-ynyl)-2-thiophenecarboxylic acid; 886505-51-7 (CAS); Thiophene-2-carboxylic acid derivative with hydroxy-methylbutynyl substituent.
EINECS	Contact for details

Quality Control

Our production of 5-(3-Hydroxy-3-Methylbut-1-Yn-1-Yl)Thiophene-2-Carboxylic Acid adheres to stringent quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures material consistency and traceability, supporting our clients' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed after opening to minimize exposure to atmospheric moisture and light. For long-term storage, consider using desiccants and storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.