Description

3-Chloro-2,4-Difluorobenzyl Bromide is a versatile and high-value halogenated benzyl bromide building block essential for advanced organic synthesis. Its molecular structure, featuring chlorine and fluorine substituents on the aromatic ring, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of novel small-molecule drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluoro and chloro motifs enhance biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with tailored properties.
• Cross-Coupling Reactions: An effective electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Derivatization Agent: Used to introduce the benzyl bromide functional group into complex molecules for further chemical modification or labeling.

Basic Information

Product Name	3-Chloro-2,4-Difluorobenzyl Bromide
CAS No.	886501-15-1
Molecular Formula	C7H4BrClF2
Molecular Weight	241.46 g/mol
Synonyms	1-(Bromomethyl)-3-chloro-2,4-difluorobenzene; (3-Chloro-2,4-difluorophenyl)methyl bromide; 2,4-Difluoro-3-chlorobenzyl bromide; α-Bromo-3-chloro-2,4-difluorotoluene; Benzene, 1-(bromomethyl)-3-chloro-2,4-difluoro-; 3-Chloro-2,4-difluorobenzylbromide
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-2,4-Difluorobenzyl Bromide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by techniques such as HPLC, GC, NMR, and IR spectroscopy is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Typical 98-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.