Description

4-Nitrobenzyl Bromide is a versatile and highly reactive organic intermediate, primarily valued for its role as a key benzylating agent in synthetic organic chemistry. Its significance lies in its ability to introduce the 4-nitrobenzyl protecting group, which is crucial for the synthesis of complex molecules in pharmaceutical and agrochemical research. This compound is essential for R&D chemists and process development scientists working in fine chemical synthesis, particularly for the production of active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing various APIs, especially those requiring the 4-nitrobenzyl group as a protective moiety.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides.
• Peptide Chemistry: Employed as a protecting group for carboxylic acids during solid-phase and solution-phase peptide synthesis.
• Material Science Research: Serves as a precursor in the development of specialty polymers and advanced organic materials.
• Chemical Biology: Utilized in the synthesis of probes and reagents for studying biological systems.
• Dye and Pigment Manufacturing: Acts as an intermediate in the production of certain nitroaromatic dyes.

Basic Information

Product Name	4-Nitrobenzyl Bromide
CAS No.	100-11-8
Molecular Formula	C7H6BrNO2
Molecular Weight	216.03 g/mol
Synonyms	p-Nitrobenzyl Bromide; α-Bromo-4-nitrotoluene; 1-(Bromomethyl)-4-nitrobenzene; 4-Nitro-α-bromotoluene; PNBB; (4-Nitrophenyl)methyl Bromide; 4-Nitrobenzylbromide
EINECS	202-818-1

Quality Control

Our 4-Nitrobenzyl Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and industrial applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of our global customer base in the fine chemical and pharmaceutical sectors.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	98 - 102 °C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.