Description

4-(2-Methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-ylamino)-butyric acid is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic core structure. This compound is of significant value for research and development in medicinal chemistry, particularly in the synthesis of novel small-molecule therapeutics. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing kinase inhibitors and other targeted therapies. The material's specific molecular architecture makes it a critical building block for probing biological pathways and creating new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of potential drug candidates, especially in oncology and anti-inflammatory research.
• Kinase Inhibitor Development: Its benzo[4,5]thieno[2,3-d]pyrimidine scaffold is a privileged structure for designing and screening compounds that modulate kinase activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead molecules.
• Biochemical Tool Compound: Can be utilized to develop probes for studying specific enzyme functions and cellular signaling pathways in academic and industrial settings.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D programs.

Basic Information

Product Name	4-(2-Methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-ylamino)-butyric acid
CAS No.	886499-90-7
Molecular Formula	C₁₇H₂₁N₃O₂S
Molecular Weight	331.43 g/mol
Synonyms	4-[(2-Methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)amino]butanoic acid; 4-(2-Methyl-5,6,7,8-tetrahydro-4H-benzo[4,5]thieno[2,3-d]pyrimidin-4-ylamino)butyric acid; Butanoic acid, 4-[(2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)amino]-; 886499-90-7; 4-(2-Methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-ylamino)butanoic acid
EINECS	Contact for details

Quality Control

Our production of 4-(2-Methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-ylamino)-butyric acid adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP guidelines for early-phase development. Our quality commitment supports reliable and reproducible results in your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.