Description

(2,7-Dimethyl-5,6,7,8-Tetrahydro-Benzo[4,5]-Thieno[2,3-D]Pyrimidin-4-Ylamino)-Acetic Acid is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its role as a critical building block in the synthesis of novel, targeted therapeutic agents, offering researchers and manufacturers a reliable and well-characterized starting material. It is primarily needed by pharmaceutical R&D teams and fine chemical producers engaged in developing kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitors for oncology and inflammatory disease research.
• Biochemical Research: Used as a reference standard or ligand in enzymatic assays and structure-activity relationship (SAR) studies.
• Medicinal Chemistry: Serves as a core scaffold for the design and optimization of new chemical entities (NCEs) with targeted biological activity.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to construct complex molecular architectures for advanced material and agrochemical research.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(2,7-Dimethyl-5,6,7,8-Tetrahydro-Benzo[4,5]-Thieno[2,3-D]Pyrimidin-4-Ylamino)-Acetic Acid
CAS No.	886498-86-8
Molecular Formula	C₁₆H₁₉N₃O₂S
Molecular Weight	317.41 g/mol
Synonyms	4-[(Carboxymethyl)amino]-2,7-dimethyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine; N-[(2,7-Dimethyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)]glycine; Glycine, N-[(2,7-dimethyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)]-; (2,7-Dimethyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-ylamino)acetic acid; THTP-Glycine derivative; Kinase inhibitor intermediate 886498-86-8
EINECS	Contact for details

Quality Control

Our (2,7-Dimethyl-5,6,7,8-Tetrahydro-Benzo[4,5]-Thieno[2,3-D]Pyrimidin-4-Ylamino)-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.