Description

2,6-Difluoro-3-Methoxybenzyl Bromide is a high-value fluorinated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both fluorine and bromine substituents, makes it an essential intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorine-containing drug candidates targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the difluoro-methoxy motif can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for synthesizing specialized monomers, ligands, or functional materials that require precise fluorine substitution patterns.
• Cross-Coupling Reactions: The benzyl bromide moiety acts as an effective electrophile in various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form new carbon-carbon bonds.
• Ligand and Catalyst Development: Utilized in the preparation of novel fluorinated ligands for catalysis or in the modification of molecular scaffolds to study structure-activity relationships (SAR).
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Details
Product Name	2,6-Difluoro-3-Methoxybenzyl Bromide
CAS No.	886498-55-1
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	1-(Bromomethyl)-2,6-difluoro-3-methoxybenzene; (2,6-Difluoro-3-methoxyphenyl)methyl Bromide; 3-Methoxy-2,6-difluorobenzyl Bromide; 2,6-Difluoro-3-methoxybenzylbromide; α-Bromo-2,6-difluoro-3-methoxytoluene; 2,6-Difluoro-m-anisyl Bromide
EINECS	Contact for details

Quality Control

Every batch of 2,6-Difluoro-3-Methoxybenzyl Bromide is produced and tested under a strict quality management system. We employ advanced analytical techniques, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee full traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.