Description

3-Chloro-4-Fluorobenzyl Mercaptan is a versatile organosulfur building block characterized by its reactive thiol (-SH) and substituted benzyl groups. This compound matters as a critical intermediate for synthesizing more complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing sulfur-containing scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the benzyl mercaptan moiety imparts specific biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of functional polymers, liquid crystals, and organic electronic materials.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Bioconjugation Chemistry: Potential use in bioconjugation techniques for attaching payloads to proteins or antibodies due to the reactive thiol group.

Basic Information

Product Name	3-Chloro-4-Fluorobenzyl Mercaptan
CAS No.	886498-16-4
Molecular Formula	C7H6ClFS
Molecular Weight	176.64 g/mol
Synonyms	(3-Chloro-4-fluorophenyl)methanethiol; 3-Chloro-4-fluorobenzenemethanethiol; 3-Chloro-4-fluorobenzylthiol; α-Chloro-α-fluoro-p-toluenethiol; 1-Chloro-2-fluoro-4-(mercaptomethyl)benzene; 4-Fluoro-3-chlorobenzyl mercaptan; (3-Chloro-4-fluorobenzyl)thiol; 886498-16-4
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Fluorobenzyl Mercaptan is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. Keep the container in a cool, dry, well-ventilated place away from incompatible materials such as strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.