Description

3-Chloro-5-Fluoro-4-Methoxybenzyl Bromide is a high-purity, multi-functional halogenated benzyl bromide building block essential for advanced organic synthesis. Its value lies in its reactive benzylic bromide group and strategically positioned chloro and fluoro substituents, enabling precise molecular construction. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a versatile starting material for constructing sophisticated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty monomers for advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The benzylic bromide is an effective electrophile in various cross-coupling methodologies (e.g., Suzuki, Negishi) to form carbon-carbon bonds.
• Derivatization Agent: Useful for introducing the 3-chloro-5-fluoro-4-methoxybenzyl moiety into larger molecular architectures to modify physical, chemical, or biological properties.

Basic Information

Product Name	3-Chloro-5-Fluoro-4-Methoxybenzyl Bromide
CAS No.	886497-36-5
Molecular Formula	C8H7BrClFO
Molecular Weight	253.50 g/mol
Synonyms	1-(Bromomethyl)-3-chloro-5-fluoro-4-methoxybenzene; (3-Chloro-5-fluoro-4-methoxyphenyl)methyl bromide; 4-Methoxy-3-chloro-5-fluorobenzyl bromide; α-Bromo-3-chloro-5-fluoro-4-methoxytoluene; 3-Chloro-5-fluoro-4-methoxybenzylbromide; 886497-36-5; Benzene, 1-(bromomethyl)-3-chloro-5-fluoro-4-methoxy-
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Fluoro-4-Methoxybenzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the light-sensitive nature and reactive benzylic bromide group, it is recommended to store under an inert atmosphere for long-term stability and to minimize potential decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.