Description

4,5-Difluoro-2-Methylindole-3-Carboxylic Acid Ethyl Ester is a high-value fluorinated indole derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its precise molecular architecture, featuring strategically placed fluorine atoms, makes it indispensable for constructing complex heterocyclic scaffolds with enhanced biological activity and metabolic stability. This compound is primarily sought after by pharmaceutical R&D and fine chemical synthesis teams for the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory therapies.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and plant growth regulators leveraging the fluorine effect.
• Material Science: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials requiring fluorinated indole motifs.
• Chemical Biology & Proteomics: Employed as a molecular probe or tag due to its reactive indole core and fluorine NMR signature.
• Academic & Contract Research: Essential for methodological studies in fluorination chemistry and heterocycle synthesis.

Basic Information

Product Name	4,5-Difluoro-2-Methylindole-3-Carboxylic Acid Ethyl Ester
CAS No.	886362-67-0
Molecular Formula	C13H11F2NO2
Molecular Weight	251.23 g/mol
Synonyms	Ethyl 4,5-Difluoro-2-methyl-1H-indole-3-carboxylate; 4,5-Difluoro-2-methylindole-3-carboxylic acid ethyl ester; 1H-Indole-3-carboxylic acid, 4,5-difluoro-2-methyl-, ethyl ester; 2-Methyl-4,5-difluoroindole-3-carboxylic acid ethyl ester; 886362-67-0; Ethyl 4,5-difluoro-2-methylindole-3-carboxylate
EINECS	Contact for details

Quality Control

Every batch of 4,5-Difluoro-2-Methylindole-3-Carboxylic Acid Ethyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical documentation, including HPLC, NMR, and MS data, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A Certificate of Analysis (COA) is supplied with each shipment, detailing all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.