Description

2-Amino-5-(4-Fluorophenyl)-1,3-Thiazole-4-Carbohydrazide is a high-purity, advanced pharmaceutical intermediate characterized by its distinct thiazole core and fluorinated aromatic system. This compound matters for its critical role as a versatile building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. Pharmaceutical research and development organizations, as well as fine chemical manufacturers, need this material to drive innovation in drug discovery programs, especially for developing candidates with potential anti-infective or anti-inflammatory properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting specific enzyme pathways.
• Antimicrobial Agent Research: Serves as a core scaffold for developing new classes of antibacterial and antifungal compounds due to the thiazole moiety.
• Kinase Inhibitor Development: Utilized in medicinal chemistry for creating potential kinase inhibitors, leveraging its ability to form hydrogen bonds.
• Chemical Biology Probes: Used in research to create molecular probes for studying biological processes and target identification.
• Agrochemical Intermediate: Potential use in the synthesis of advanced crop protection agents with specific activity.
• Material Science Research: Investigated as a building block for specialty polymers or ligands in catalytic systems.

Basic Information

Product Name	2-Amino-5-(4-Fluorophenyl)-1,3-Thiazole-4-Carbohydrazide
CAS No.	886361-58-6
Molecular Formula	C10H9FN4OS
Molecular Weight	252.27 g/mol
Synonyms	2-Amino-5-(4-fluorophenyl)-4-thiazolecarbohydrazide; 5-(4-Fluorophenyl)-2-amino-1,3-thiazole-4-carbohydrazide; 4-Thiazolecarbohydrazide, 2-amino-5-(4-fluorophenyl)-; 886361-58-6; 2-Amino-5-(p-fluorophenyl)-1,3-thiazole-4-carbohydrazide; 5-(4-Fluorophenyl)-2-amino-δ²-thiazoline-4-carbohydrazide; (4-Fluorophenyl)thiazole carbohydrazide derivative
EINECS	Contact for details

Quality Control

Our 2-Amino-5-(4-Fluorophenyl)-1,3-Thiazole-4-Carbohydrazide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.