Description

Methyl 3-(2-Amino-4-Fluorophenoxy)-2-Thiophenecarboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold combining a fluorinated aniline moiety with a thiophene carboxylate ester. This compound matters for its critical role as a versatile building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular design. Pharmaceutical R&D teams and fine chemical manufacturers need this intermediate to develop next-generation drugs, leveraging its structural complexity for creating potent and selective candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides, where the fluorophenoxy-thiophene structure offers unique bioactivity.
• Material Science: Serves as a monomer or functional additive in the research of specialty polymers and organic electronic materials.
• Chemical Synthesis: Employed as a versatile building block for constructing complex heterocyclic compounds in medicinal and process chemistry.
• Academic & Industrial R&D: Essential for research laboratories focused on fluorine chemistry, heterocyclic compound synthesis, and structure-activity relationship (SAR) studies.

Basic Information

Product Name	Methyl 3-(2-Amino-4-Fluorophenoxy)-2-Thiophenecarboxylate
CAS No.	886360-59-4
Molecular Formula	C12H10FNO3S
Molecular Weight	267.28 g/mol
Synonyms	Methyl 3-[(2-amino-4-fluorophenyl)oxy]-2-thiophenecarboxylate; 2-Thiophenecarboxylic acid, 3-[(2-amino-4-fluorophenyl)oxy]-, methyl ester; 3-(2-Amino-4-fluorophenoxy)thiophene-2-carboxylic acid methyl ester; Methyl 3-(2-amino-4-fluorophenoxy)thiophene-2-carboxylate; 886360-59-4; CAS 886360-59-4
EINECS	Contact for details

Quality Control

Our production of Methyl 3-(2-Amino-4-Fluorophenoxy)-2-Thiophenecarboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.