Description

(E)-6-Iodo-3-[2-(Pyridin-2-Yl)Ethenyl]-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is a high-purity, advanced pharmaceutical intermediate featuring a unique indazole core functionalized with an iodinated aromatic ring and a vinylpyridine moiety. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of targeted small molecule therapeutics. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other novel drug candidates, particularly for oncology and inflammatory disease applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent and selective kinase inhibitors for targeted cancer therapies.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Probe Development: Used to create labeled or tagged molecules for studying biological pathways and target engagement.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical-stage compounds.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug design methodologies.

Basic Information

Product Name	(E)-6-Iodo-3-[2-(Pyridin-2-Yl)Ethenyl]-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole
CAS No.	886230-77-9
Molecular Formula	C19H18IN3O
Molecular Weight	431.27 g/mol
Synonyms	6-Iodo-3-[(E)-2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; (E)-6-Iodo-3-(2-pyridylvinyl)-1-(tetrahydropyran-2-yl)-1H-indazole; THP-Protected 6-Iodo-3-styrylindazole; 1H-Indazole, 6-iodo-3-[2-(2-pyridinyl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-, (E)-; 886230-77-9; 6-Iodo-3-[(E)-2-(2-pyridinyl)vinyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
EINECS	Contact for details

Quality Control

Our (E)-6-Iodo-3-[2-(Pyridin-2-Yl)Ethenyl]-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.