Description

(E)-6-Nitro-3-[2-(Pyridin-2-Yl)Ethenyl]-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is a high-purity, advanced pharmaceutical intermediate characterized by its unique indazole core functionalized with a nitro group and a pyridine-containing ethenyl substituent. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel, biologically active molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within oncology and inflammation research.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates targeting specific enzymes or receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new chemical entities.
• Biochemical Tool Compound: May be utilized in vitro to study biological pathways and mechanisms of action.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.
• Academic Research: Used in university laboratories for fundamental research in heterocyclic and synthetic organic chemistry.

Basic Information

Product Name	(E)-6-Nitro-3-[2-(Pyridin-2-Yl)Ethenyl]-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole
CAS No.	886230-75-7
Molecular Formula	C19H18N4O3
Molecular Weight	350.37 g/mol
Synonyms	6-Nitro-3-[(E)-2-(2-pyridinyl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; 1-(Oxan-2-yl)-6-nitro-3-[(E)-2-(pyridin-2-yl)ethenyl]indazole; (E)-6-Nitro-3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; THP-protected nitro-indazole derivative; 886230-75-7; 6-Nitro-3-styryl-1-THP-indazole (pyridine variant)
EINECS	Contact for details

Quality Control

Our production of (E)-6-Nitro-3-[2-(Pyridin-2-Yl)Ethenyl]-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming the product meets the agreed specifications for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.