Description

8-Bromo-1,3,4,5-tetrahydrobenzo[b]azepine-2-one is a high-purity, advanced pharmaceutical intermediate featuring a brominated benzazepinone scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Organic Synthesis Building Block: The bromine atom provides a reactive site for further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Chemical Reference Standard: Serves as an analytical standard for quality control and method development in API manufacturing.
• Biochemical Tool Compound: Potential use in probing biological pathways and protein interactions in preclinical research.

Basic Information

Product Name	8-Bromo-1,3,4,5-tetrahydrobenzo[b]azepine-2-one
CAS No.	885953-12-8
Molecular Formula	C10H10BrNO
Molecular Weight	240.10 g/mol
Synonyms	8-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-one; 8-Bromo-1,2,3,5-tetrahydro-4H-benzo[b]azepin-4-one; 8-Bromobenzazepinone; 8-Bromo-2-azabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-one; 8-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
EINECS	Contact for details

Quality Control

Our 8-Bromo-1,3,4,5-tetrahydrobenzo[b]azepine-2-one is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.