Description

4-Bromo-3-Iodo-6-(1H)Indazole Carboxylic Acid is a high-purity, multi-halogenated indazole derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique halogen substitution pattern, which provides distinct reactivity and electronic properties for constructing complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical development teams engaged in medicinal chemistry, particularly for the synthesis of novel heterocyclic compounds and targeted small molecule libraries.

Application

• Pharmaceutical Intermediate: A key precursor in the research and development of new active pharmaceutical ingredients (APIs), especially those targeting kinase inhibition or other heterocycle-dependent mechanisms.
• Medicinal Chemistry: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Research: Serves as a building block for developing novel herbicides, fungicides, or plant growth regulators that incorporate halogenated indazole motifs.
• Material Science: Potential monomer or precursor for synthesizing specialized organic electronic materials or metal-organic frameworks (MOFs) due to its halogenated aromatic structure.
• Chemical Biology: Employed in the synthesis of molecular probes and tool compounds for studying biological pathways and protein functions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and fine chemical manufacturers performing bespoke synthesis for client projects.

Basic Information

Item	Detail
Product Name	4-Bromo-3-Iodo-6-(1H)Indazole Carboxylic Acid
CAS No.	885523-54-6
Molecular Formula	C8H4BrIN2O2
Molecular Weight	366.94 g/mol
Synonyms	6-Bromo-7-iodo-1H-indazole-3-carboxylic acid; 4-Bromo-3-iodo-1H-indazole-6-carboxylic acid; 1H-Indazole-6-carboxylic acid, 4-bromo-3-iodo-; 885523-54-6; 4-Br-3-I-6-(1H)Indazole-COOH; 6-Bromo-7-iodoindazole-3-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-3-Iodo-6-(1H)Indazole Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and mass spectrometry is supplied with each shipment. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.