Description

4-Fluoro-6-Nitro-3-(1H)Indazole Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its indazole core functionalized with fluorine and nitro groups. This compound matters for its critical role as a key building block in the synthesis of novel, targeted small-molecule therapeutics, particularly kinase inhibitors. Pharmaceutical R&D and fine chemical manufacturers need this precise intermediate to develop next-generation treatments for oncology and inflammatory diseases, where its specific substitution pattern is essential for biological activity.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of potent kinase inhibitors and other biologically active molecules.
• Oncology Drug Discovery: Used in research and development of targeted cancer therapies due to its indazole scaffold, which is common in many drug candidates.
• Chemical Biology Research: Serves as a versatile scaffold for creating chemical probes to study enzyme function and signal transduction pathways.
• Agrochemical Development: Potential use in the synthesis of novel herbicides or fungicides, leveraging its heterocyclic structure.
• Material Science Research: Exploration as a monomer or functional component in the development of specialty polymers and advanced organic materials.

Basic Information

Product Name	4-Fluoro-6-Nitro-3-(1H)Indazole Carboxylic Acid
CAS No.	885522-59-8
Molecular Formula	C8H4FN3O4
Molecular Weight	225.14 g/mol
Synonyms	4-Fluoro-6-nitro-1H-indazole-3-carboxylic acid; 1H-Indazole-3-carboxylic acid, 4-fluoro-6-nitro-; 4-Fluoro-6-nitroindazole-3-carboxylic acid; 885522-59-8; 4-Fluoro-6-nitro-3-indazolecarboxylic acid; 4-Fluoro-6-nitro-1H-indazole-3-carboxylic acid; 3-Carboxy-4-fluoro-6-nitroindazole
EINECS	Contact for details

Quality Control

Our 4-Fluoro-6-Nitro-3-(1H)Indazole Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.