Description

3-Chloro-6-Fluoro-4-Indazolecarboxylic Acid Methyl Ester is a high-value, multi-functional heterocyclic building block essential for modern synthetic chemistry. This compound is a critical intermediate in the research and development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor programs. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of targeted cancer therapeutics, especially kinase inhibitors.
• Agrochemical Research: Used in the development of new herbicides and pesticides due to its bioactive indazole core.
• Material Science: Serves as a precursor for advanced organic electronic materials and liquid crystals.
• Chemical Biology: Employed as a molecular probe or scaffold in drug discovery and biochemical studies.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs for bespoke chemical synthesis.

Basic Information

Item	Details
Product Name	3-Chloro-6-Fluoro-4-Indazolecarboxylic Acid Methyl Ester
CAS No.	885521-77-7
Molecular Formula	C9H6ClFN2O2
Molecular Weight	228.61 g/mol
Synonyms	Methyl 3-chloro-6-fluoro-1H-indazole-4-carboxylate; 3-Chloro-6-fluoro-1H-indazole-4-carboxylic acid methyl ester; 1H-Indazole-4-carboxylic acid, 3-chloro-6-fluoro-, methyl ester; 885521-77-7; 3-Chloro-6-fluoroindazole-4-carboxylic acid methyl ester; Methyl 3-chloro-6-fluoroindazole-4-carboxylate
EINECS	Contact for details

Quality Control

Our 3-Chloro-6-Fluoro-4-Indazolecarboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.