Description

3-Iodoindazole-5-Carboxylic Acid is a high-value, heterocyclic building block featuring both an iodine substituent and a carboxylic acid functional group. This unique bifunctional structure makes it a critical intermediate for the synthesis of complex molecules in advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and material science industries for constructing novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of targeted drug candidates, particularly in kinase inhibitor and oncology research programs.
• Agrochemical Development: Used to create novel active ingredients for crop protection products, leveraging its halogenated indazole core.
• Material Science Research: Serves as a building block for organic electronic materials, metal-organic frameworks (MOFs), and specialty polymers.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological pathways and protein interactions.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create diverse compound libraries.
• Ligand Synthesis: The carboxylic acid group allows for derivatization into amides and esters, useful for creating chelating ligands in catalysis.

Basic Information

Product Name	3-Iodoindazole-5-Carboxylic Acid
CAS No.	885521-46-0
Molecular Formula	C8H5IN2O2
Molecular Weight	288.04 g/mol
Synonyms	3-Iodo-1H-indazole-5-carboxylic acid; 5-Carboxy-3-iodoindazole; 1H-Indazole-5-carboxylic acid, 3-iodo-; 3-Iodo-1H-indazole-5-carboxylate; 885521-46-0; 3-Iodoindazole-5-CA
EINECS	Contact for details

Quality Control

Our 3-Iodoindazole-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.